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Unwanted Effects of GnRHa Puberty Blockers

The table below lists the known side effects, but some of these effects may actually be the desired therapeutic effects in certain medical contexts.

It’s important to understand that people can have varying responses to medications, and what one person experiences may differ from another. If a specific side effect is not listed, it’s less likely to be directly caused by the medication, but this does not rule out the possibility entirely.

In cases where you suspect a medication may be causing an unwanted effect, adjusting the medication, trying an alternative treatment, or discontinuing the medication can help clarify whether the side effect is medication-related or has another underlying cause.

Side Effects
Very Common (> 10%)
Asthenia / Weakness
Decreased Hemoglobin
Mood Changes
Hot Flush (73%)
Hypertension / High Blood Pressure (14%)
Hyperhidrosis / Increased Sweating
Impotence (40%)
Urinary Tract Infection (12%)
Erectile Dysfunction (10%)
Dysuria / Painful Urination
Painful Sex
Painful Periods
Pelvic Pain
Vulvovaginal Dryness
Bleeding/Spotting
Genital Hemorrhage (Including Menorrhagia And Metrorrhagia)
Increased Liver Enzymes
Increased Glucose
Influenza (16%)
Paresthesia / tingling In Lower Limbs
Skeletal Pain (13%)
Back Pain (11%)
Common (1%-10%)
Abnormal Liver Function
Anemia
Bronchitis
Coughing
Dyspnea / Trouble Breathing
Pharyngitis
Dependent Edema / Swelling
Diabetes Mellitus/High Blood Sugar
Anorexia
Eye Pain
Conjunctivitis
Headache
Dizziness
Tiredness
Hypersensitivity Reaction
Injection Site Pain
Injection Site Reactions
Injection Site Erythema
Injection Site Inflammation
Insomnia
Feeling Emotional
Loss Of Libido
Depression
Depressed Mood
Irritability
Leg Pain
Peripheral Edema / Swelling / Swelling
Back Pain
Tiredness
Chest Pain
Edema / Swelling
Nausea
Vomiting
Constipation
Dyspepsia
Diarrhea
Abdominal / Stomach Pain
Abdominal Discomfort
Pain In Extremity
Arthralgia (Joint Pains)
Edema / Swelling In Legs
Leg Cramps
Myalgia (Muscle Pains)
Musculoskeletal Pain
Muscle Spasms
Rash
Pruritus / Itching
Testicular Atrophy
Breast Pain
Gynecomastia / Breast Growth
Urinary Retention
Abdominal / Stomach Pain Upper
Dry Mouth
Acne
Alopecia / Hair Loss
Allergic Reactions
Asthma Aggravated
Blood Creatinine Increased
Embolism
Gama-Glutamyl Transferase Increased
Lethargy
Pain
Rigors
Blood Lactate Dehydrogenase Increased
Blood Cholesterol Increased
Muscle Cramp
Muscular Weakness
Testicular Pain
Tinnitus / Ringing in the Ears
Sleepiness
Paresthesia / tingling
Weight Increased
Gout
Increased Appetite
Weight Decreased
Rare (< 0.1%)
Abdominal Bloating
Taste Disturbance
Flatulence / Wind
Abnormal Sensation In Eye
Visual Disturbance
Anaphylactic Reaction
Hypersensitivity
Blood Alkaline Phosphatase Increased
Confusional State
Decreased Activity
Euphoric Mood
Ejaculation Failure
Hypotension / Low Blood Pressure
Joint Stiffness
Joint Swelling
Musculoskeletal Stiffness
Osteoarthritis
Orthopnea
Epistaxis
Nasopharyngitis
Purpura / Bruising
Blister
Pyrexia / High Temperature
Influenza Like Illness
Body Temperature Increased
Vertigo
Dysstasia
Memory Impairment
Anaphylactic Shock
AngioEdema / Swelling
Chills
Gastralgia
Increased Lymphocyte Count
Testosterone Levels Increased
Testosterone Levels Decreased
Increased Bone Loss
Osteoporosis
Bone Fracture
Bone Disorder
Epiphysiolysis
Slipped Capital Femoral Epiphysis
Worsening Of Neuropathy
Spinal Cord Compression With Weakness Or Paralysis Of The Lower Extremities
Unkown Frequency
Amenorrhea
Angioneurotic Edema / Swelling
Urticaria / Itching
Anxiety
Affect Lability
Nervousness
Blood Pressure Increased
Thromboembolic Events Including
But Not Limited To
Pulmonary Emboli
Cerebrovascular Accident
Myocardial Infarction
Deep Venous Thrombosis
Transient Ischemic Attack (mini-stroke)
And Thrombophlebitis
Bone Pain
Convulsions / Fits
Malaise / Feeling Unwell
Pituitary Adenoma
Pituitary Apoplexy
Vision Blurred
The Majority Of Pituitary Apoplexy Cases Occurred Within 2 Weeks Of The First Dose
Some Within The First Hour. In These Cases, Pituitary Apoplexy Presented As Sudden Headache
Vomiting
Visual Changes
Ophthalmoplegia
Altered Mental Status
And Sometimes Cardiovascular Collapse. Immediate