Progesterone is a naturally occurring hormone found in both cisgender (non-transgender) and transgender individuals. In the context of gender-affirming care, progesterone may be prescribed to transgender women and individuals assigned male at birth (AMAB) to help promote feminising physical characteristics and align their external appearance with their gender identity.
Preparations
| Product Type | Brand / Name | Active Ingredient | How It’s Usually Taken | Key Notes |
|---|---|---|---|---|
| Tablets | Utrogestan 100 mg / 200 mg | Micronised progesterone | Taken by mouth, often at bedtime due to drowsiness | Avoid alcohol near dose; may cause sleepiness |
| Lugesteron | Micronised progesterone | Taken orally, often at bedtime | Similar to Utrogestan in effect and side effects | |
| Bijuve / Bijuva | Estradiol + micronised progesterone | One tablet daily, same time each day | Combines both hormones in one pill; not suitable for all women (oestrogen-containing) | |
| Suppositories / Pessaries (Vaginal or Rectal) | Utrogestan | Micronised progesterone | Inserted into the vagina, usually once or twice daily | Less drowsiness than oral; local absorption |
| Cyclogest | Progesterone | Inserted vaginally or rectally as instructed | May cause leakage | |
| Vaginal Gel | Crinone Gel | Progesterone | Applied once daily or as prescribed | Can cause some residue; convenient single-use applicators |
How Does Progesterone Work?
Progesterone is one of the hormones involved in regulating the menstrual cycle and pregnancy in cisgender women. In gender-affirming care, it is used to complement oestrogen therapy to enhance certain feminising effects.
Using Progesterone for Gender-Affirming Care
For transgender women and AMAB individuals seeking feminisation, progesterone therapy can be a component of their gender-affirming journey. The goal is to develop a more feminine appearance and alleviate gender dysphoria.
Administration of Progesterone
Progesterone can be administered in various forms, including oral tablets, vaginal or rectal tablets and topical creams. The choice of administration method depends on individual preferences, medical considerations, and expert recommendations.
Potential Changes and Effects of Progesterone
The introduction of progesterone into the body may lead to various physical and emotional changes over time, including:
- Development of breast tissue
- Softening of the skin
- Changes in mood and emotions
- Possible changes in libido
It’s important to note that the feminising effects of progesterone can vary among individuals, and not everyone may experience the same results.
Dosage and Monitoring
The dosage of progesterone and the frequency of administration will be determined by your healthcare provider based on your specific needs and goals. Regular monitoring of hormone levels and overall health is essential to ensure the safe and effective use of progesterone.
Potential Side Effects and Considerations
While progesterone therapy is generally safe, it may be associated with some side effects as seen in cisgender women, including:
- Mood swings or emotional changes
- Breast tenderness
- Changes in appetite and weight
Be sure to discuss any concerns or side effects during your treatment.
You can read more about side effects here.