| Side Effect | Description |
| Skin irritation | Some individuals may experience skin irritation or redness at the application site of Lenzetto. This can include itching, burning, or discomfort. |
| Breast tenderness and enlargement | Lenzetto therapy, like other forms of estrogen therapy, can cause breast tenderness, soreness, and enlargement due to the promotion of breast tissue development. |
| Nausea | Nausea or gastrointestinal discomfort may occur as a side effect of Lenzetto therapy, though this is usually mild and transient. |
| Headaches | Headaches are a common side effect of estrogen therapy, including Lenzetto use. These headaches may range from mild to moderate in severity. |
| Mood changes | Some individuals may experience mood swings, emotional sensitivity, or changes in emotional well-being while taking Lenzetto therapy. |
| Fluid retention | Lenzetto therapy can lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body. |
| Weight changes | Some individuals may experience changes in body weight or distribution as a side effect of Lenzetto therapy. |
| Skin changes | Lenzetto therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation. |
| Decreased libido | A decrease in libido (sex drive) can occur as a side effect of Lenzetto therapy due to changes in hormone levels. |
| Fatigue | Fatigue or feelings of lethargy may occur as a side effect of Lenzetto therapy, particularly during the initial period of adjustment. |
| Decreased fertility | Lenzetto therapy can suppress sperm production and fertility in individuals assigned male at birth. It’s essential to discuss fertility preservation options with a healthcare provider if fertility preservation is desired. |
| Thromboembolic events | While less common, there is a risk of thromboembolic events (such as blood clots) associated with Lenzetto therapy, particularly in individuals with other risk factors for thrombosis. |
| Rare allergic reactions | Although rare, some individuals may experience allergic reactions to Lenzetto, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |