Cyclogest side effects

Cyclogest is a brand name for progesterone suppositories containing micronised progesterone, a natural form of the hormone progesterone. While it is more commonly used in the context of fertility treatments and hormonal support during pregnancy, it has also been used off-label in gender-affirming care for transgender women (assigned male at birth) or individuals with androgen-dependent conditions. Progesterone therapy is often prescribed in combination with oestrogen therapy to help promote breast development and mimic the hormonal profile of cisgender women. Here are some potential unwanted/adverse/side effects of Cyclogest in the context of gender-affirming care:

Side Effect	Description
Gastrointestinal discomfort	Some individuals may experience gastrointestinal discomfort, such as bloating, gas, or abdominal pain, as a side effect of using Cyclogest suppositories.
Vaginal discharge or irritation	Insertion of suppositories may cause vaginal discharge or irritation in some individuals.
Mood changes	Progesterone therapy, including Cyclogest use, may lead to mood changes, including mood swings, irritability, or changes in emotional well-being.
Fatigue	Fatigue or feelings of lethargy may occur as a side effect of Cyclogest therapy.
Headaches	Headaches are a common side effect of progesterone therapy, including Cyclogest use. These headaches may range from mild to moderate in severity.
Breast tenderness and enlargement	Progesterone therapy can cause breast tenderness, soreness, and enlargement due to its effects on breast tissue development.
Fluid retention	Progesterone therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Weight changes	Some individuals may experience changes in body weight or distribution as a side effect of progesterone therapy.
Skin changes	Progesterone therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation.
Menstrual-like bleeding	Some individuals may experience breakthrough bleeding or spotting while using Cyclogest suppositories, particularly if they have not undergone surgical removal of the gonads.
Rare allergic reactions	Although rare, some individuals may experience allergic reactions to Cyclogest, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary.