Estradiol tablets contain synthetic oestrogen, a hormone crucial for the development of female secondary sexual characteristics. Administered orally, these tablets provide a systemic delivery of estradiol, facilitating feminization by inducing changes such as breast development, redistribution of body fat, and softening of skin texture. These changes contribute to gender affirmation and support individuals in expressing their authentic gender identity.
| Feature | Estradiol 1mg / 2mg (Generic) | Progynova | Elleste Solo |
|---|---|---|---|
| Active ingredient | Estradiol (17β-estradiol) | Estradiol valerate (a prodrug that converts to estradiol) | Estradiol (17β-estradiol) |
| Available strengths | 1 mg, 2 mg | 1 mg, 2 mg | 1 mg, 2 mg |
| How it's processed in body | Direct estradiol | Converted to estradiol after absorption | Direct estradiol |
| Typical dose in feminising HRT | Often 1–2 mg/day | Often 1–2 mg/day | Often 1–2 mg/day |
| Brand vs Generic | Generic – can be more cost-effective, widely available | Brand (Bayer) | Brand (Exeltis) |
| Benefits | Flexibility, affordability, well-studied | Trusted brand; possibly stable supply | Another branded option; familiarity for some prescribers |
How to Take It
Swallow the tablet with water.
Take it at around the same time each day.
If you forget a dose, skip the missed one and take the next dose at your usual time.
It may take several weeks (often around 3 months) before you notice significant feminising effects.
Possible Side Effects
Affirming effects you may see:
Breast development (typically over months)
Softer, more elastic skin
Redistribution of body fat toward hips, thighs, and other traditionally feminine patterns
Reduced muscle mass or strength (depending on anti-androgen use)
Common side-effects (especially early on):
Nausea
Headache
Breast tenderness
Mood changes, bloating, or fluid retention
Spotting or bleeding (if still having periods or depending on other hormone use)
Less common but serious risks:
Risk of blood clots (venous thromboembolism), especially with oral oestrogen.
Other cardiovascular risks; these depend on individual risk factors.
Liver concerns (because oral oestrogen is processed in the liver)