| Side Effect | Description |
| Breast Tenderness and Enlargement | Estradiol enanthate injections can lead to breast tenderness, soreness, and enlargement due to the stimulation of breast tissue development. |
| Mood Changes | Some individuals may experience mood swings, irritability, or changes in emotional wellbeing as a result of estradiol enanthate therapy. |
| Fatigue | Fatigue or feelings of lethargy may occur as a side effect of estradiol enanthate therapy, particularly during the initial period of adjustment. |
| Headaches | Headaches are a common side effect of estrogen therapy, including estradiol enanthate use. These headaches may range from mild to moderate in severity. |
| Nausea | Nausea or gastrointestinal discomfort may occur as a side effect of estradiol enanthate therapy, though this is usually mild and transient. |
| Fluid Retention | Estradiol enanthate therapy can lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body. |
| Weight Changes | Some individuals may experience changes in body weight or distribution as a side effect of estradiol enanthate therapy. |
| Skin Changes | Estradiol enanthate therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation. |
| Decreased Libido | A decrease in libido (sex drive) can occur as a side effect of estradiol enanthate therapy due to changes in hormone levels. |
| Thromboembolic Events | While less common, there is a risk of thromboembolic events (such as blood clots) associated with estradiol enanthate therapy, particularly in individuals with other risk factors for thrombosis. |