Side Effect | Description |
Liver function abnormalities | Bicalutamide may cause liver toxicity, including elevated liver enzymes. Periodic monitoring of liver function through blood tests is recommended during treatment. |
Breast tenderness and enlargement | Similar to other anti-androgen medications, bicalutamide can cause breast tenderness and enlargement due to its suppression of testosterone and promotion of estrogenic effects. |
Hot flashes | Some individuals may experience hot flashes or flushing as a side effect of bicalutamide treatment. |
Gastrointestinal issues | Bicalutamide can cause gastrointestinal symptoms such as nausea, vomiting, diarrhea, or stomach discomfort in some individuals. |
Decreased libido | A decrease in libido (sex drive) can occur as a side effect of bicalutamide treatment due to its anti-androgenic effects. |
Erectile dysfunction | Bicalutamide may cause erectile dysfunction or difficulty achieving/maintaining erections in individuals assigned male at birth. |
Fatigue | Some users may experience increased fatigue or feelings of lethargy while taking bicalutamide. |
Muscle weakness | Weakness or decreased muscle strength can occur as a side effect of bicalutamide treatment. |
Thromboembolic events | While less common, there is a risk of thromboembolic events (such as blood clots) associated with bicalutamide use, particularly in individuals with other risk factors for thrombosis. |
Osteoporosis | Long-term use of bicalutamide can potentially increase the risk of osteoporosis due to decreased bone density. Bone density monitoring and supplementation with calcium and vitamin D may be recommended. |
Mood changes | Some individuals may experience mood swings, depression, or changes in emotional well-being while taking bicalutamide. |
Rare allergic reactions | Although rare, some individuals may experience allergic reactions to bicalutamide, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |