Spironolactone is a medication commonly used in gender-affirming care for transgender women. It is a potassium-sparing diuretic and aldosterone antagonist that also has anti-androgenic properties. Spironolactone works by blocking the action of androgens (male sex hormones) and reducing the production of testosterone, thereby helping to feminize the body by reducing masculine features such as facial and body hair growth, muscle mass, and oiliness of the skin. Here's a detailed guide to the administration of spironolactone:
Administration
Preparation
Spironolactone tablets are typically taken orally with or without food.
Before taking spironolactone, read the medication label and any accompanying member information leaflet.
Timing
Take spironolactone tablets at the same time each day to maintain consistent levels of the medication in your body.
Follow the prescribed dosing schedule, and do not skip doses or alter the dosage without consulting them.
Administration Technique
Swallow the spironolactone tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect the release of the medication.
If you have difficulty swallowing tablets, talk to your healthcare provider about alternative options, such as cutting the tablet into smaller pieces or switching to a different formulation.
Post-Administration Care
After taking spironolactone, wash your hands thoroughly with soap and water to remove any residue from handling the medication.
Store the medication in a cool, dry place away from direct sunlight and moisture, following any storage instructions provided by the medication label.
Considerations
Spironolactone is often used in combination with oestrogen therapy to block the effects of testosterone and enhance the feminizing effects of oestrogen in transgender women.
Adhere to the prescribed dosage and dosing schedule to achieve the desired treatment outcomes.
Regular monitoring of hormone levels and potassium is essential to evaluate treatment effectiveness and adjust the dosage if necessary.