GnRHa Puberty Blocker Side Effects

The below table lists the known side effects, but some of these effects may actually be the desired therapeutic effects in certain medical contexts.

Different people can have different responses to medications. If a side effect is not listed, it’s less likely to be caused by the medication, but does not rule out the possibility.

If you suspect a medication may be causing a side effect, adjust the medication, try an alternative treatment, or stop using the medication help see if the side effect is medication-related or has another cause.


Side Effects

Very Common (>10%)Common (1-10%)Rare (<0.1%)Unknown Frequency
Asthenia / WeaknessAbnormal Liver FunctionAbdominal BloatingAmenorrhea
Decreased HemoglobinAnemiaTaste DisturbanceAngioneurotic Edema / Swelling
Mood ChangesBronchitisFlatulence / WindUrticaria / Itching
Hot Flush (73%)CoughingAbnormal Sensation In EyeAnxiety
Hypertension / High Blood Pressure (14%)Dyspnea / Trouble BreathingVisual DisturbanceAffect Lability
Hyperhidrosis / Increased SweatingPharyngitisAnaphylactic ReactionNervousness
Impotence (40%)Dependent Edema / SwellingHypersensitivityBlood Pressure Increased
Urinary Tract Infection (12%)Diabetes Mellitus/High Blood SugarBlood Alkaline Phosphatase IncreasedThromboembolic Events Including
Erectile Dysfunction (10%)AnorexiaConfusional StateBut Not Limited To
Dysuria / Painful UrinationEye PainDecreased ActivityPulmonary Emboli
Painful SexConjunctivitisEuphoric MoodCerebrovascular Accident
Painful PeriodsHeadacheEjaculation FailureMyocardial Infarction
Pelvic PainDizzinessHypotension / Low Blood PressureDeep Venous Thrombosis
Vulvovaginal DrynessTirednessJoint StiffnessTransient Ischemic Attack (mini-stroke)
Bleeding/SpottingHypersensitivity ReactionJoint SwellingAnd Thrombophlebitis
Genital Hemorrhage (Including Menorrhagia And Metrorrhagia)Injection Site PainMusculoskeletal StiffnessBone Pain
Increased Liver EnzymesInjection Site ReactionsOsteoarthritisConvulsions / Fits
Increased GlucoseInjection Site ErythemaOrthopneaMalaise / Feeling Unwell
Influenza (16%)Injection Site InflammationEpistaxisPituitary Adenoma
Paresthesia / tingling In Lower LimbsInsomniaNasopharyngitisPituitary Apoplexy*
Skeletal Pain (13%)Feeling EmotionalPurpura / BruisingVision Blurred
Back Pain (11%)Loss Of LibidoBlisterVomiting

DepressionPyrexia / High TemperatureVisual Changes

Depressed MoodInfluenza Like IllnessOphthalmoplegia

IrritabilityBody Temperature IncreasedAltered Mental Status

Leg PainVertigoAnd Sometimes Cardiovascular Collapse. Immediate.

Peripheral Edema / Swelling / SwellingDysstasia

Back PainMemory Impairment

TirednessAnaphylactic Shock

Chest PainAngioEdema / Swelling

Edema / SwellingChills

NauseaGastralgia

VomitingIncreased Lymphocyte Count

ConstipationTestosterone Levels Increased

DyspepsiaTestosterone Levels Decreased

DiarrheaIncreased Bone Loss

Abdominal / Stomach PainOsteoporosis

Abdominal DiscomfortBone Fracture

Pain In ExtremityBone Disorder

Arthralgia (Joint Pains)Epiphysiolysis

Edema / Swelling In LegsSlipped Capital Femoral Epiphysis

Leg CrampsWorsening Of Neuropathy

Myalgia (Muscle Pains)Spinal Cord Compression With Weakness Or Paralysis Of The Lower Extremities

Musculoskeletal Pain


Muscle Spasms


Rash


Pruritus / Itching


Testicular Atrophy


Breast Pain


Gynecomastia / Breast Growth


Urinary Retention


Abdominal / Stomach Pain Upper


Dry Mouth


Acne


Alopecia / Hair Loss


Allergic Reactions


Asthma Aggravated


Blood Creatinine Increased


Embolism


Gama-Glutamyl Transferase Increased


Lethargy


Pain


Rigors


Blood Lactate Dehydrogenase Increased


Blood Cholesterol Increased


Muscle Cramp


Muscular Weakness


Testicular Pain


Tinnitus / Ringing in the Ears


Sleepiness


Paresthesia / tingling