Vaniqa (eflornithine) 11.5% cream is primarily indicated for the reduction of unwanted facial hair growth. Here are potential unwanted/adverse/side effects of Vaniqa cream in the context of gender-affirming care:
| Side Effect | Description |
| Skin irritation | Some individuals may experience skin irritation, redness, itching, or burning at the application site of Vaniqa cream. |
| Acne | Vaniqa cream may exacerbate acne or cause acne-like breakouts in some individuals. |
| Stinging or tingling | Sensations of stinging or tingling at the application site may occur, particularly during initial use of Vaniqa cream. |
| Hair bumps (folliculitis) | Some individuals may develop hair bumps or folliculitis, which are inflamed or infected hair follicles, as a side effect of Vaniqa cream. |
| Dry skin | Vaniqa cream may cause dryness of the skin at the application site. |
| Headache | Headache is a less common side effect of Vaniqa cream but may occur in some individuals. |
| Eye irritation | Avoiding contact with the eyes is important when applying Vaniqa cream, as it may cause irritation if it comes into contact with the eyes. |
| Allergic reactions | Although rare, some individuals may experience allergic reactions to Vaniqa cream, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |
https://www.ema.europa.eu/en/documents/product-information/vaniqa-epar-product-information_en.pdf