Utrogestan is a medication containing micronised progesterone, a natural form of the hormone progesterone, commonly used in gender-affirming care for transgender women (assigned male at birth) or individuals with androgen-dependent conditions. It is often prescribed in combination with estrogen therapy to help promote breast development and mimic the hormonal profile of cisgender women. While progesterone therapy can be beneficial for some individuals, it’s important to be aware of potential unwanted/adverse/side effects. Here are some of them:
| Side Effect | Description |
| Breast tenderness and enlargement | Progesterone therapy, including Utrogestan, can cause breast tenderness, soreness, and enlargement due to its effects on breast tissue development. |
| Mood changes | Some individuals may experience mood swings, irritability, or changes in emotional well-being while taking Utrogestan therapy. |
| Fatigue | Fatigue or feelings of lethargy may occur as a side effect of Utrogestan therapy. |
| Headaches | Headaches are a common side effect of progesterone therapy, including Utrogestan use. These headaches may range from mild to moderate in severity. |
| Nausea | Nausea or gastrointestinal discomfort may occur as a side effect of Utrogestan therapy, though this is usually mild and transient. |
| Changes in libido | Some individuals may experience changes in libido (sex drive) while taking Utrogestan therapy. |
| Fluid retention | Progesterone therapy can lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body. |
| Weight changes | Some individuals may experience changes in body weight or distribution as a side effect of Utrogestan therapy. |
| Skin changes | Progesterone therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation. |
| Menstrual-like bleeding | Some individuals may experience breakthrough bleeding or spotting while taking Utrogestan therapy, particularly if they have not undergone surgical removal of the gonads. |
| Sleep disturbances | Progesterone therapy may affect sleep patterns in some individuals, leading to insomnia or disrupted sleep. |
| Rare allergic reactions | Although rare, some individuals may experience allergic reactions to Utrogestan, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |