Unwanted Effects of Spironolactone

Unwanted Effects of Spironolactone

The table below lists the known side effects, but some of these effects may actually be the desired therapeutic effects in certain medical contexts.

It’s important to understand that people can have varying responses to medications, and what one person experiences may differ from another. If a specific side effect is not listed, it’s less likely to be directly caused by the medication, but this does not rule out the possibility entirely.

In cases where you suspect a medication may be causing an unwanted effect, adjusting the medication, trying an alternative treatment, or discontinuing the medication can help clarify whether the side effect is medication-related or has another underlying cause.

Side Effects
Very Common (> 10%)
– Gynecomastia / Breast Growth (13%)
Common (1%-10%)
– Hyperkalemia / High Potassium Levels
– Hyponatremia / Low Sodium Levels
– Paresthesia / tingling
– Low Libido
– Malaise / Feeling Unwell
– Nausea
– Vomiting
– Weakness
Uncommon (0.1%-1%)
– Confusion
– Muscle Spasms
– Leg Cramps
– Rash
– Urticaria / Itching
– Erythema
– Chloasma
– Pruritus / Itching
– Exanthema
– Serum Creatinine Elevated
Rare (< 0.1%)
– Dehydration
– Porphyria
– Hyperuricemia
– Eczema
– Hypersensitivity
– Paralysis
– Paraplegia Of The Limbs Due To Hyperkalemia
– Thrombocytopenia
– Eosinophilia
– Leukopenia
Very Rare (< 0.01%)
– Acute Renal Failure
– Alopecia / Hair Loss
– Erythema Annulare Centrifugum
– Hypertrichosis
– Breast Cancer
– Gastric Inflammation
– Gastric Ulcers
– Intestinal Hemorrhage
– Cramps
– Hepatitis
– Systemic Lupus Erythematosus
– Osteomalacia
– Vasculitis
Unkown Frequency
– Agranulocytosis
– Anaphylactic Reactions
– Breast Disorders In Women
– Slight Androgenic Effects
– Breast Tenderness
– Voice Deepening
– Breast Pain
– Digestive System Disorders
– Diarrhea
– Indigestion
– Gastric Bleeding
– Tiredness
– Fever
– Headache
– Drowsiness
– Dizziness
– Ataxia
– Hirsutism / Hairiness
– Stevens-Johnson Syndrome
– Toxic Epidermal Necrolysis
– Drug Rash With Eosinophilia And Systemic Symptoms (DRESS)
– Maculopapular Or Erythematous Cutaneous Eruptions
– Libido Reduced In Men
– Mild Hypotension / Low Blood Pressure
– Mixed Cholestatic/Hepatocellular Toxicity
– Renal Dysfunction
– Reproductive System Disorders
– Erectile Dysfunction
– Impotence
– Reversible Hyperchloremic Metabolic Acidosis In People With Decompensated Liver Cirrhosis
– Electrolyte Disturbances
– Other Adverse Effects
– High Blood Sugar
– Impaired Neurologic Function/Coma In People With Liver Impairment
– Cirrhosis And Ascites
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