• Dosage or Administration Issues: If you’re not taking the prescribed dosage of estradiol consistently or if you’re not administering it correctly (e.g., missing doses, not applying patches properly, etc.), this could result in lower-than-expected estradiol levels.
• Individual Variation: Everyone’s body metabolises medications differently, so the same dosage of estradiol may lead to different blood levels in different individuals. Some people may require higher doses or a different preparation eg gel or patch or pill to achieve therapeutic levels.
• Drug Interactions: Certain medications, supplements, or herbal remedies can interfere with the absorption, metabolism, or effectiveness of estradiol, leading to lower levels in the bloodstream.
• Liver Function: Estradiol is metabolised by the liver, so if you have liver issues or impaired liver function, it may affect the metabolism and clearance of estradiol from your body, resulting in lower levels.
• Lab Errors: Sometimes, lab errors or variability in testing methods can lead to inaccuracies in estradiol level measurements. It’s essential to ensure that the blood tests are conducted using reliable methods and that the results are interpreted correctly.
• Body Weight: Body weight and body fat percentage can influence hormone levels. Higher body fat levels can lead to increased conversion of estradiol to estrone, a less potent estrogen, potentially resulting in lower estradiol levels.
• Timing of Blood Tests: The timing of blood tests concerning your last dose of estradiol can affect the measured levels. For example, if you have your blood drawn just before your next dose, your estradiol levels may appear lower than they actually are.
• Adherence to Treatment: If you’re not consistently adhering to your hormone therapy regimen as prescribed by your healthcare provider, this could contribute to lower estradiol levels.

If you’re concerned about your estradiol levels being lower than expected, then have a think about the issues listed above. If you would like to talk to someone about your specific case then you can book that here.