Testosterone Enanthate – common side effects

Testosterone Enanthate – common side effects

Testosterone enanthate is a commonly used injectable testosterone ester and is often prescribed for testosterone replacement therapy in men with hypogonadism. It is also used off-label in gender-affirming care for transgender men (assigned female at birth) to masculinise secondary sexual characteristics. Here are potential unwanted/adverse/side effects of testosterone enanthate in the context of gender-affirming care:

Side EffectDescription
AcneTestosterone therapy, including testosterone enanthate, can increase sebum production, leading to acne or exacerbating existing acne.
Increased body hair growthOne of the desired effects of testosterone therapy in transgender men is increased body hair growth. However, excessive hair growth or unwanted hair growth in certain areas may occur.
Male pattern baldnessTestosterone therapy can accelerate male pattern baldness in individuals who are genetically predisposed to it.
Voice deepeningTestosterone therapy may cause voice deepening in transgender men due to vocal cord thickening.
Clitoral enlargementTestosterone therapy may lead to clitoral enlargement in transgender men due to tissue growth in the clitoral region.
Menstrual changesTestosterone therapy typically leads to cessation of menstruation (amenorrhea) in transgender men, but irregular bleeding or spotting may occur during the initial stages of treatment.
Emotional changesSome individuals may experience emotional changes, such as increased aggression or irritability, while taking testosterone therapy.
Weight gain or redistributionTestosterone therapy may lead to changes in fat distribution, with increased muscle mass and decreased fat in certain areas.
Increased libidoTestosterone therapy often increases libido (sex drive) in transgender men.
Mood changesTestosterone therapy may lead to mood changes, including mood swings, increased energy levels, or changes in emotional well-being.
Fluid retentionTestosterone therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Changes in cholesterol levelsTestosterone therapy may affect cholesterol levels, leading to increases in LDL cholesterol (“bad” cholesterol) and decreases in HDL cholesterol (“good” cholesterol).

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