Tadalafil is a medication primarily used to treat erectile dysfunction in transgender individuals. Some transgender women might use it off-label to address erectile dysfunction, particularly during hormone therapy. Here are potential unwanted/adverse/side effects of tadalafil:
| Side Effect | Description |
| Headache | Headache is one of the most common side effects of tadalafil use. It may range from mild to severe. |
| Flushing | Some individuals may experience facial flushing or warmth as a side effect of tadalafil. |
| Indigestion | Tadalafil may cause indigestion, stomach discomfort, or acid reflux in some individuals. |
| Muscle aches | Some users may experience muscle aches or pains, particularly in the back, arms, or legs, as a side effect of tadalafil. |
| Nasal congestion | Tadalafil may cause nasal congestion or stuffiness in some individuals. |
| Vision changes | Rarely, tadalafil may cause vision changes such as blurred vision, changes in color vision, or increased sensitivity to light. |
| Dizziness | Tadalafil may cause dizziness or lightheadedness, particularly when standing up from a sitting or lying position. |
| Priapism | Priapism is a rare but serious side effect of tadalafil characterized by a prolonged erection lasting more than four hours. It requires immediate medical attention to prevent tissue damage to the penis. |
| Hearing loss | In rare cases, tadalafil use has been associated with sudden hearing loss or ringing in the ears (tinnitus). |
| Allergic reactions | Although uncommon, some individuals may experience allergic reactions to tadalafil, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |
Note: If you feel like you might benefit from sildenafil for erectile dysfunction, you can purchase a recommendation for sildenafil as an add-on (for £10) when you submit your Treatment Recommendation request form.