Provera, also known as medroxyprogesterone acetate, is a synthetic progestin commonly used in various medical contexts, including hormone replacement therapy and birth control. In the context of gender-affirming care for transgender women (assigned male at birth) or individuals with androgen-dependent conditions, it may be prescribed to help promote breast development and mimic the hormonal profile of cisgender women. However, it’s important to be aware of potential unwanted/adverse/side effects. Here are some of them:
| Side Effect | Description |
| Breast tenderness and enlargement | Provera therapy can cause breast tenderness, soreness, and enlargement due to its effects on breast tissue development. |
| Mood changes | Some individuals may experience mood swings, irritability, or changes in emotional well-being while taking Provera therapy. |
| Fatigue | Fatigue or feelings of lethargy may occur as a side effect of Provera therapy. |
| Headaches | Headaches are a common side effect of Provera therapy. These headaches may range from mild to moderate in severity. |
| Nausea | Nausea or gastrointestinal discomfort may occur as a side effect of Provera therapy, though this is usually mild and transient. |
| Fluid retention | Provera therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body. |
| Weight changes | Some individuals may experience changes in body weight or distribution as a side effect of Provera therapy. |
| Skin changes | Provera therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation. |
| Menstrual-like bleeding | Provera therapy can cause breakthrough bleeding or spotting, particularly during the initial stages of treatment. |
| Decreased libido | Some individuals may experience a decrease in libido (sex drive) while taking Provera therapy. |
| Rare allergic reactions | Although rare, some individuals may experience allergic reactions to Provera, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |