Ovestin (estriol) 0.1% intravaginal cream is a medication primarily used to treat symptoms of vaginal atrophy, such as dryness, itching, and discomfort. Here are some potential side effects of Ovestin in the context of gender-affirming care:
| Side Effect | Description |
| Vaginal irritation | Some individuals may experience vaginal irritation, itching, or discharge as a side effect of using Ovestin cream. |
| Breast tenderness | Estriol, the active ingredient in Ovestin, may cause breast tenderness or soreness in some individuals. |
| Mood changes | Hormone therapy, including estrogen therapy, may lead to mood changes, including mood swings, irritability, or changes in emotional well-being. |
| Headaches | Headaches are a common side effect of estrogen therapy. These headaches may range from mild to moderate in severity. |
| Nausea | Nausea or gastrointestinal discomfort may occur as a side effect of estrogen therapy, though this is usually mild and transient. |
| Fluid retention | Estrogen therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body. |
| Skin changes | Estrogen therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation. |
| Menstrual-like bleeding | Some individuals may experience breakthrough bleeding or spotting while using estrogen therapy, particularly during the initial stages of treatment. |
| Rare allergic reactions | Although rare, some individuals may experience allergic reactions to Ovestin cream, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |
https://www.medsafe.govt.nz/profs/datasheet/o/Ovestinvagcrm.pdf