Bijuve is a medication that combines estradiol and progesterone, used in hormone replacement therapy (HRT) for postmenopausal women to relieve symptoms of menopause and in gender-affirming care. It’s important to understand the potential unwanted/adverse/side effects that could be relevant in the context of gender-affirming care. Here are some potential side effects:
| Breast tenderness/enlargement | Both estradiol and progesterone can cause breast tenderness, soreness, and enlargement due to their effects on breast tissue development. |
| Mood changes | Hormone therapy, including estradiol and progesterone, may lead to mood changes, including mood swings, irritability, or changes in emotional well-being. |
| Fatigue | Fatigue or feelings of lethargy may occur as a side effect of hormone therapy. |
| Headaches | Headaches are a common side effect of hormone therapy. These headaches may range from mild to moderate in severity. |
| Nausea | Nausea or gastrointestinal discomfort may occur as a side effect of hormone therapy, though this is usually mild and transient. |
| Fluid retention | Hormone therapy may lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body. |
| Weight changes | Some individuals may experience changes in body weight or distribution as a side effect of hormone therapy. |
| Skin changes | Hormone therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation. |
| Menstrual-like bleeding | Some individuals may experience breakthrough bleeding or spotting while using hormone therapy, particularly during the initial stages of treatment. |
| Rare allergic reactions | Although rare, some individuals may experience allergic reactions to hormone therapy, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur. |
https://media.healthdirect.org.au/medicines/GuildLink_Information/367690/CMI/ttcbijuv10922.pdf