Spironolactone acts as an aldosterone antagonist, and this action can complicate the management of POTS, especially if you’re taking medications like fludrocortisone, which is often used in POTS treatment to regulate blood pressure and volume.
If you are considering taking spironolactone and are also being treated for POTS please let us and your usual healthcare provider know. We or they can suggest alternative medications that don't interfere with POTS treatment. Adjusting medication should always be done under medical supervision to ensure both your gender-affirming and POTS treatment needs are safely and effectively met.
Make sure that all your healthcare providers are aware of your complete medication list, so they can coordinate care and provide the safest and most effective treatment options.